Recipharm announces collaboration with Oz-UK to accelerate the development of low global warming potential pMDIs utilising HFA-152a propellant

December 5, 2023

Simon Gardner appointed to support customers to transition to greener propellants,  bringing 20 years of experience with HFA-152a supplier Koura 

Global contract development and manufacturing organisation (CDMO), Recipharm has today announced a collaboration with Oz-UK, a Contract Research Organisation (CRO) and provider of solutions for respiratory R&D, to accelerate the development and manufacture of “green” pressurised metered dose inhalers (pMDIs). The pMDIs will utilise valves and actuators from  Recipharm’s Bespak® brand, and a new generation of low global warming potential (GWP)  propellants. 

This collaboration will see Recipharm and Oz-UK join forces to advance environmentally-friendly pMDIs, capitalising upon the strengths and capabilities of the two organisations to ensure the fastest possible pathway to market for customers. The first formulations will feature Koura’s Zephex® HFA-152a, a sustainable medical propellant which significantly reduces the device’s overall carbon footprint.  

Recipharm is able to offer its customers a choice of green propellants to use in pMDIs, investing significantly in its product development and manufacturing capability and capacity to meet demand. Earlier this year, the CDMO also announced its collaboration with Honeywell to develop pMDIs featuring the Honeywell Solstice® Air (HFO-1234ze(E)) cGMP, as well as embarking upon significant expansion of its commercial scale pMDI manufacturing capabilities at its Holmes Chapel,  UK site.  

To lead the transition to greener propellants for customers, Recipharm has appointed Simon  Gardner as Business Development Specialist for pMDIs. Gardner joins from Koura and brings over  20 years of experience in the medical propellant industry to the role. 

Chris Hirst, President, Advanced Delivery Systems at Recipharm said: “Vital to a successful transition for our customers is having access to a team of experts to help guide them through the process. Simon’s wealth of experience in medical propellants, including the launch of Zephex®  HFA-152a during his time at Koura, means our customers will be in safe hands as he helps them  navigate the move to greener devices.”  

Oz-UK has invested in its laboratory infrastructure to enable customer programmes to be delivered with unparalleled speed and responsiveness. Opening a second site during 2023, it will be enhanced further by mid-2024, with the addition of capacity to enable the manufacturing of solution and suspension pMDIs containing low GWP propellants, HFA-152a and HFO-1234ze (E), for use in development programmes. 

Chris Hirst, President, Advanced Delivery Systems at Recipharm said: “Oz-UK has an excellent reputation for innovation in methods and processes for accelerating the early stages of product formulation. This relationship will enable us to bring greener pMDIs to the patients who rely on  them to treat chronic illnesses such as asthma and COPD more quickly than ever before.” 

David Lewis, Co-founder, Oz-UK said: “Recipharm’s agility in adapting to the challenges of the new greener propellants is impressive, and a big part of what attracted us to work with them. We’ve requested specific valve builds and have been able to put them on products and test them in our lab within a week. This is the speed that is needed for success in the transition to low-GWP  propellants, and we are excited to see our clients’ programmes accelerate as a result of this  collaboration.” 

Chris Hirst added: “With the manufacturing expertise and development capabilities to support a  choice of propellant, and a team of experts on hand at both Recipharm and Oz-UK to support our  customers, we are well placed to become the partner of choice for companies developing  sustainable pMDIs for respiratory care.” 

Recipharm Advanced Delivery Systems is now Bespak, a global contract development and manufacturing organisation (CDMO) focused on inhaled and nasal drug delivery devices and drug-device combination products.

About Bespak

Bespak is a global contract development and manufacturing organisation (CDMO) focused on inhaled and nasal drug delivery devices and drug-device combination products. Bespak develops and manufactures finished pharmaceutical products, as well as being a leading global supplier of drug delivery devices and componentry to the pharmaceutical industry. With a long history in the development and commercial supply of pressurised Metered Dose Inhalers (pMDIs), Bespak supplies a major proportion of the world’s pMDI dosing valves and actuators, and also specialises in the industrialisation and high-volume manufacture of complex dry powder inhaler (DPI) devices.

Headquartered in Holmes Chapel, UK, the company’s service offering spans early-stage feasibility, analytical services and product development, from pilot-scale, through to clinical supply and commercial-scale drug product fill-finish, device and component manufacturing.

More information:

About Oz-UK 

Oz-UK is a contract research organisation specialising in pressurised metered dose inhaler (pMDI) and liquid aerosol research & development. Oz-UK provides a one stop shop for early-phase discovery, formulation and  scale-up. Oz-UKs management team have over 75 years of combined experience in pMDI technology from bench to product. Our team are inventors of some of the most significant pMDI formulation valve, canister, and actuator patents over the past three decades and have successfully commercialised several market leading pMDI technologies. 

For more information on Oz-UK, please visit

For further information and interview opportunities with Bespak, please contact:

Sarah Guinane at Notch Communications

[email protected]

You may also like